The best route from regions along Hwy 40 and South of Hwy 40 is I-44.

I-270 South to I-44 East
Exit at Jaimeson and turn LEFT
At the T (Arsenal) turn LEFT
Turn RIGHT on MacCausland
At Clayton road, proceed STRAIGHT through the intersection
(MacCausland turns into Skinker at this point)
LEFT on Forsyth
RIGHT at Tolman Way

The best route from regions North of Hwy 40 is I-70 or I-364 (turns into Page at 270).

I-70 OR I-364 (Page) to I-170 South
EXIT Forest Park Parkway
East on Forest Park Parkway
RIGHT on Skinker
RIGHT on Forsyth
RIGHT at Tolman Way